Team 2 : “Regulation of allogeneic immune responses in renal transplantation”

Tuesday 5 May 2015

Team leader

Titre : DR1. CNRS.
Last name : MOONEY
Name : Nuala
Mail :
Secretariat :
Tél. : 33 (0)1 42 38 53 46
Research Theme
List of members


Dr Lara Zafrani est lauréate du prix de recherche de l’European Society of Intensive Care Medicine (ESCIM) 2016

#ESOT2015Brussels - State of The Art 5 presented by Denis Glotz - YouTube



Research Theme

“Regulation of allogeneic immune responses in renal transplantation”

The project of this team is based upon recent data regarding immunological mechanisms implicated in decreased allograft survival. Progress in the development of immunosuppressive therapies pre- and post-organ transplantation have led to the emergence of a new profile of allograft damage. The most frequent time course of rejection is now chronic rather than acute. To date mediators of chronic rejection have been identified only in the context of their association with the clinical outcome of transplantation and neither the basic immunobiology nor potential for intervention have been examined. The project encompasses three complementary axes of research : (i) the role of endothelial cells in the initiation and regulation of the alloimmune response leading to chronic antibody-mediated rejection (AMR); (ii) the mechanisms of HLA class II antibody pathogenesis ; (iii) innate immune response regulation of allograft survival.

List of members

MOONEY Nuala dr1 cnrs
Alloanticorps et cellules endothéliales en transplantation
Nuala Mooney DR1 CNRS
Denis Glotz PPH P7
Carmen Lefaucheur PPH P7
Jean-Luc Taupin PU-PH P7
Lara Zafrani MCU-PH P7
Julien Lion Post-doctorant P7
Amy Cross Doctorant P7
Caroline Suberbielle PH APHP
Maryvonnick Carmagnat PH APHP
Andrey Zaytsev M2 P6
Cellules myéloides et inflammation en transplantation
Alain Haziot DR2 INSERM
Didier Payen PPH P7
Marie-Noelle Péraldi PPH P7
Valerie Faivre IE P7 (Larib.)
Benjamin Chousterman CCA P7
Benjamin Huot PH APHP
Benjamin Soyer CCA P7
Samuel Gauguin CCA P7
Karine Poussin IE INSERM
Shannon Cohen Doctorant P7
Fadila Mourah Doctorant P7


  1. Lion J, Taflin C, Cross AR, Robledo-Sarmiento M, Mariotto E, Savenay A,
    Carmagnat M, Suberbielle C, Charron D, Haziot A, Glotz D, Mooney N. HLA class II
    antibody activation of endothelial cells promotes Th17 and disrupts regulatory T
    lymphocyte expansion. Am J Transplant. 2015 Nov 28. doi: 10.1111/ajt.13644. [Epub
    ahead of print] PubMed PMID: 26614587.
  2. Xu-Dubois YC, Peltier J, Brocheriou I, Suberbielle-Boissel C, Djamali A, Reese
    S, Mooney N, Keuylian Z, Lion J, Ouali N, Levy PP, Jouanneau C, Rondeau E, Hertig
    A. Markers of Endothelial-to-Mesenchymal Transition: Evidence for
    Antibody-Endothelium Interaction during Antibody-Mediated Rejection in Kidney
    Recipients. J Am Soc Nephrol. 2016 Jan;27(1):324-32. doi: 10.1681/ASN.2014070679.
    Epub 2015 May 20. PubMed PMID: 25995444; PubMed Central PMCID: PMC4696562.
  3. Lefaucheur C, Viglietti D, Bentlejewski C, Duong van Huyen JP, Vernerey D,
    Aubert O, Verine J, Jouven X, Legendre C, Glotz D, Loupy A, Zeevi A. IgG
    Donor-Specific Anti-Human HLA Antibody Subclasses and Kidney Allograft
    Antibody-Mediated Injury. J Am Soc Nephrol. 2016 Jan;27(1):293-304. doi:
    10.1681/ASN.2014111120. Epub 2015 Aug 20. PubMed PMID: 26293822; PubMed Central
    PMCID: PMC4696574.
  4. Viglietti D, Gosset C, Loupy A, Deville L, Verine J, Zeevi A, Glotz D,
    Lefaucheur C. C1-Inhibitor in Acute Antibody-Mediated Rejection Non-Responsive to
    Conventional Therapy in Kidney Transplant Recipients: A Pilot Study. Am J
    Transplant. 2015 Dec 22. doi: 10.1111/ajt.13663. [Epub ahead of print] PubMed
    PMID: 26693703.
  5. Glotz D, Tambur A. Stratifying Patients Based on Epitope Mismatching: Ready
    for Primetime? Am J Transplant. 2015 Aug;15(8):2021-2. doi: 10.1111/ajt.13343.
    Epub 2015 Jun 11. PubMed PMID: 26095902.
  6. Tambur AR, Herrera ND, Haarberg KM, Cusick MF, Gordon RA, Leventhal JR,
    Friedewald JJ, Glotz D. Assessing Antibody Strength: Comparison of MFI, C1q, and
    Titer Information. Am J Transplant. 2015 Sep;15(9):2421-30. doi:
    10.1111/ajt.13295. Epub 2015 Apr 30. PubMed PMID: 25930984.


in the same section...

  • Team 2 : “Regulation of allogeneic immune responses in renal transplantation”